Publications

2024

Torres G, Salladay-Perez IA, Dhingra A, Covarrubias AJ. Genetic origins, regulators, and biomarkers of cellular senescence. Trends in Genetics. 40(12):1018-1031.

2022

Heckenbach, I., Mkrtchyan, G.V., Ezra, M.B., Bakula, D., Madsen, J.S., Nielsen, M.H., Oró, D. Osborne, B., Covarrubias, A.J., Idda, M.L., Gorospe, M., Mortensen, L., Verdin, E., Westendorp, R., Scheibye-Knudsen, M. Nuclear morphology is a deep learning biomarker of cellular senescence. Nature Aging2, 742–755.

2021

Covarrubias, Anthony J., Rosalba Perrone, Alessia Grozio, and Eric Verdin. “NAD + Metabolism and Its Roles in Cellular Processes during Ageing.” Nature Reviews Molecular Cell Biology 22 (2): 119–41.

2020

Covarrubias, A.J., Abhijit Kale, Rosalba Perrone, Jose Alberto Lopez-Dominguez, Angela Oliveira Pisco, Herbert G. Kasler, Mark S. Schmidt, et al. n.d. “Senescent Cells Promote Tissue NAD + Decline during Ageing via the Activation of CD38 + Macrophages.” Nature Metabolism.

2019

Covarrubias, Anthony J., Abhijit Kale, Rosalba Perrone, Jose Alberto Lopez-Dominguez, Angela Oliveira Pisco, Herbert G. Kasler, Mark S. Schmidt, et al. “Aging-Related Inflammation Driven by Cellular Senescence Enhances NAD Consumption via Activation of CD38+ pro-Inflammatory Macrophages.” BioRxiv, 609438.

2017

Newman, John C., Anthony J. Covarrubias, Minghao Zhao, Xinxing Yu, Philipp Gut, Che-Ping Ng, Yu Huang, Saptarsi Haldar, and Eric Verdin. “Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.” Cell Metabolism26 (3): 547-557.e8.

2016

Covarrubias, Anthony J, Halil Ibrahim Aksoylar, Jiujiu Yu, Nathaniel W Snyder, Andrew J Worth, Shankar S Iyer, Jiawei Wang, et al. “Akt-MTORC1 Signaling Regulates Acly to Integrate Metabolic Input to Control of Macrophage Activation.”ELife 5: e11612.

Covarrubias, Anthony Joseph. The Role of Nutrient Sensing in Macrophage Polarization. Doctoral dissertation, Harvard University, Graduate School of Arts & Sciences.

2015

Covarrubias, Anthony J., H. Ibrahim Aksoylar, and Tiffany Horng. “Control of Macrophage Metabolism and Activation by MTOR and Akt Signaling.” Seminars in Immunology, Macrophage activation and polarization, 27 (4): 286–96.

2014

Covarrubias, Anthony J., and Tiffany Horng. “IL-6 Strikes a Balance in Metabolic Inflammation.” Cell Metabolism 19 (6): 898–99.

2013

Byles, Vanessa, Anthony J. Covarrubias, Issam Ben-Sahra, Dudley W. Lamming, David M. Sabatini, Brendan D. Manning, and Tiffany Horng. “The TSC-MTOR Pathway Regulates Macrophage Polarization.” Nature Communications 4: 2834.

Covarrubias, Anthony, Vanessa Byles, and Tiffany Horng. “ROS Sets the Stage for Macrophage Differentiation.” Cell Research 23 (8): 984–85.

2010

Chin, Arnold I., Andrea K. Miyahira, Anthony Covarrubias, Juli Teague, Beichu Guo, Paul W. Dempsey, and Genhong Cheng. “Toll-like Receptor 3–Mediated Suppression of TRAMP Prostate Cancer Shows the Critical Role of Type I Interferons in Tumor Immune Surveillance.” Cancer Research 70 (7): 2595–2603.