Publications

2026

Salladay-Perez I, Covarrubias AJ. Cholesterol-Induced Senescent Macrophages and Evaluation of Cellular Senescence Phenotypes.Current Protocols.Accepted March 18, 2026. Published April 22, 2026. PMID: 42017459

Torres G, Tripathi U, Salladay-Perez I, Avila I, Covarrubias AJ.An In Vitro Model of Macrophage Senescence.Current Protocols.Accepted September 29, 2025. Published April 22, 2026. PMID: 42017404

Salladay-Perez IA, Avila I, Estrada L, Alexandru AC, Ponce C, Dhingra A, Torres G, Deng CY, Hegde R, Gensheimer J, Kale A, Heckenbach I, Hui S, Edillor C, Soto JA, Napior AJ, Little I, Larsen M, Rose J, Farahi L, Lopez Gonzalez EDJ, Krieger MR, Chowdhury K, Sharma M, Jiang Y, Williams K, Scheibye-Knudsen M, Koehler CM, Meyer JG, Mack JJ, Brenner C, Bensinger SJ, Lagger C, de Magalhães JP, Schilling B, Singh R, Verdin E, Lusis AJ, Covarrubias AJ. p21+TREM2+ senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease. Nature Aging. Accepted February 25, 2026, Published April 16, 2026. (Featured Cover Article-April 2026 Volume). PMID: 41991686 DOI: 10.1038/s43587-026-01101-6.

Jiang Y, Salladay-Perez I, Momenzadeh A, Covarrubias AJ, Meyer JG. Simultaneous Multi-Omics Analysis by Direct Infusion Mass Spectrometry (SMAD-MS). Angew Chem Int Ed Engl. March 30, 2026. PMID: 41906962. doi: 10.1002/anie.202519836.

McCarthy EC, Seyedsadr M, Bang MF, Pham CLH, Bustillos C, Salladay-Perez I, Whitmire JK, Lechner MG, Shieh P, Covarrubias AJ, Su MA. Pathologic T cell immunosenescence drives the development of age-associated autoimmune peripheral neuropathy. bioRxiv. January 7, 2026. (In Revision: Nature Immunology). doi: https://doi.org/10.64898/2026.01.07.698250.

2024

Torres G, Salladay-Perez IA, Dhingra A, Covarrubias AJ. Genetic origins, regulators, and biomarkers of cellular senescence. Trends in Genetics. 40(12):1018-1031.

2023

Jiang Y, Salladay-Perez I, Momenzadeh A, Covarrubias AJ, Meyer JG. Simultaneous Multi-Omics Analysis by Direct Infusion Mass Spectrometry (SMAD-MS). bioRxiv, June 29, 2023.  PMID: 37425781. PMCID: PMC10326973. doi: 10.1101/2023.06.26.546628

2022

Heckenbach, I., Mkrtchyan, G.V., Ezra, M.B., Bakula, D., Madsen, J.S., Nielsen, M.H., Oró, D. Osborne, B., Covarrubias, A.J., Idda, M.L., Gorospe, M., Mortensen, L., Verdin, E., Westendorp, R., Scheibye-Knudsen, M. Nuclear morphology is a deep learning biomarker of cellular senescence. Nature Aging2, 742–755.

Shemtov SJ, Emani R, Bielska O, Covarrubias AJ, Verdin E, Anderson J, Winer D. The intestinal immune system and gut barrier function in obesity and ageing. FEBS Journal. 2022 Jun 21;10.1111/febs.16558. PMCID: PMC9768107.

2021

Bartleson J, Radenkovic D, Covarrubias AJ, Furman D, Winer DA, Verdin E. SARS-CoV-2, COVID-19 and the aging immune system. Nature Aging. 2021 Sep; 1, 769-782. PMID: 34746804.

Covarrubias, Anthony J., Rosalba Perrone, Alessia Grozio, and Eric Verdin. “NAD + Metabolism and Its Roles in Cellular Processes during Ageing.” Nature Reviews Molecular Cell Biology 22 (2): 119–41.

2020

Covarrubias, A.J., Abhijit Kale, Rosalba Perrone, Jose Alberto Lopez-Dominguez, Angela Oliveira Pisco, Herbert G. Kasler, Mark S. Schmidt, et al. n.d. “Senescent Cells Promote Tissue NAD + Decline during Ageing via the Activation of CD38 + Macrophages.” Nature Metabolism.

2019

Covarrubias, Anthony J., Abhijit Kale, Rosalba Perrone, Jose Alberto Lopez-Dominguez, Angela Oliveira Pisco, Herbert G. Kasler, Mark S. Schmidt, et al. “Aging-Related Inflammation Driven by Cellular Senescence Enhances NAD Consumption via Activation of CD38+ pro-Inflammatory Macrophages.” BioRxiv, 609438.

2017

Newman, John C., Anthony J. Covarrubias, Minghao Zhao, Xinxing Yu, Philipp Gut, Che-Ping Ng, Yu Huang, Saptarsi Haldar, and Eric Verdin. “Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.” Cell Metabolism26 (3): 547-557.e8.

2016

Covarrubias, Anthony J, Halil Ibrahim Aksoylar, Jiujiu Yu, Nathaniel W Snyder, Andrew J Worth, Shankar S Iyer, Jiawei Wang, et al. “Akt-MTORC1 Signaling Regulates Acly to Integrate Metabolic Input to Control of Macrophage Activation.”ELife 5: e11612.

Covarrubias, Anthony Joseph. The Role of Nutrient Sensing in Macrophage Polarization. Doctoral dissertation, Harvard University, Graduate School of Arts & Sciences.

2015

Covarrubias, Anthony J., H. Ibrahim Aksoylar, and Tiffany Horng. “Control of Macrophage Metabolism and Activation by MTOR and Akt Signaling.” Seminars in Immunology, Macrophage activation and polarization, 27 (4): 286–96.

2014

Covarrubias, Anthony J., and Tiffany Horng. “IL-6 Strikes a Balance in Metabolic Inflammation.” Cell Metabolism 19 (6): 898–99.

2013

Byles, Vanessa, Anthony J. Covarrubias, Issam Ben-Sahra, Dudley W. Lamming, David M. Sabatini, Brendan D. Manning, and Tiffany Horng. “The TSC-MTOR Pathway Regulates Macrophage Polarization.” Nature Communications 4: 2834.

Covarrubias, Anthony, Vanessa Byles, and Tiffany Horng. “ROS Sets the Stage for Macrophage Differentiation.” Cell Research 23 (8): 984–85.

2010

Chin, Arnold I., Andrea K. Miyahira, Anthony Covarrubias, Juli Teague, Beichu Guo, Paul W. Dempsey, and Genhong Cheng. “Toll-like Receptor 3–Mediated Suppression of TRAMP Prostate Cancer Shows the Critical Role of Type I Interferons in Tumor Immune Surveillance.” Cancer Research 70 (7): 2595–2603.